Gaspari T, Liu H, Welungoda I, Hu Y, Widdop RE, Knudsen LB, Simpson RW, Dear AE
2021 Jun 2;13(6):1915
There are several processes that contribute to mitochondrial quality control, including UPR mt , mitophagy, mitochondrial membrane dynamics, and mitochondrial biogenesis 13,89
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The molecule makes three changes to the native hormone fragment: a lactam bridge between the aspartate side-chain carboxyl at position 5 and the lysine side-chain amine at position 10, inversion to D-phenylalanine at position 7, and substitution of norleucine for the oxidation-prone methionine at position 4